EMDB EMD-30445

Single particle reconstruction
3.2Å resolution

human KCNQ2 in complex with retigabine

Map released:
Overview of EMD-30445
Source organism: Homo sapiens [9606]
Fitted atomic model: 7cr2
Related EM entries by publication: EMD-30443, EMD-30444, EMD-30446, EMD-30447, EMD-30448
Primary publication:
Molecular basis for ligand activation of the human KCNQ2 channel.
Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J
Cell Res. - (2020)
PMID: 32884139

Function and Biology Details

Sample name: voltage-gated potassium channel KCNQ2
Ligand: ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Proteins: voltage-gated potassium channel KCNQ2, Potassium voltage-gated channel subfamily KQT member 2

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Detector: GATAN K2 SUMMIT (4k x 4k)