EMDB EMD-30301

Single particle reconstruction
2.9Å resolution

Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.

Map released:
Overview of EMD-30301
Source organism: Homo sapiens [9606]
Fitted atomic model: 7c7s
Related EM entry by publication: EMD-30300
Primary publication:
Cryo-EM structures of inactive and active GABABreceptor.
Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y
Cell Res. - (2020)
PMID: 32494023

Function and Biology Details

Sample name: The CGP54626-bound GABAB heterodimer
Ligands: N-ACETYL-D-GLUCOSAMINE, (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid
Proteins: The CGP54626-bound GABAB heterodimer, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2

Experimental Information Details

Resolution: 2.9Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)