EMDB EMD-30300

Single particle reconstruction
3.0Å resolution

Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state

Map released:
Overview of EMD-30300
Source organism: Homo sapiens [9606]
Fitted atomic model: 7c7q
Related EM entry by publication: EMD-30301
Primary publication:
Cryo-EM structures of inactive and active GABABreceptor.
Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y
Cell Res. - (2020)
PMID: 32494023

Function and Biology Details

Sample name: The baclofen/BHFF-bound GABAB heterodimer
Ligands: N-ACETYL-D-GLUCOSAMINE, (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, baclofen
Proteins: The baclofen/BHFF-bound GABAB heterodimer, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2

Experimental Information Details

Resolution: 3.0Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Detector: GATAN K2 SUMMIT (4k x 4k)