EMD-29980

Helical reconstruction
4.8 Å
EMD-29980
3D View Gallery
Deposition: 07/03/2023
Map released: 08/11/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29980
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8gf7 summary report (pdf.gz) Map and 8gf7 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils

EMD-29980

Helical reconstruction
4.8 Å
EMD-29980
3D View Gallery
Deposition: 07/03/2023
Map released: 08/11/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: alpha-synuclein fibrils
Fitted models: 8gf7

Deposition Authors: Balana JA, Nguyen AB, Saelices L , Pratt RM
O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA , Horvath M , Javed A, Hard ER, Jasiqi Y, Singh P , Afrin S, Pedretti R, Singh V , Lee VM, Luk KC, Saelices L , Lashuel HA , Pratt MR
(2024) Nat Chem Biol , 20 , 646 - 655
PUBMED: 38347213
DOI: doi:10.1038/s41589-024-01551-2
ISSN: 1552-4469