EMD-29930
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
EMD-29930
Single-particle2.94 Å
Deposition: 01/03/2023Map released: 12/07/2023
Last modified: 06/11/2024
Sample Organism:
Trypanosoma cruzi,
Escherichia coli,
Trypanosoma cruzi strain CL Brener
Sample: Topoisomerase II alpha bound to dsDNA and inhibitor CT1
Fitted models: 8gcc
Deposition Authors: Schenk A, Deniston C
,
Noeske J
Sample: Topoisomerase II alpha bound to dsDNA and inhibitor CT1
Fitted models: 8gcc
Deposition Authors: Schenk A, Deniston C
,
Noeske J
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS ,
Gould MK ,
Noeske J ,
Saldivia M ,
Jumani RS ,
Ng PS ,
Rene O,
Chen YL ,
Kaiser M ,
Ritchie R ,
Francisco AF ,
Johnson N ,
Patra D,
Cheung H,
Deniston C ,
Schenk AD ,
Cortopassi WA ,
Schmidt RS ,
Wiedemar N ,
Thomas B ,
Palkar R ,
Ghafar NA ,
Manoharan V,
Luu C ,
Gable JE,
Wan KF ,
Myburgh E ,
Mottram JC ,
Barnes W ,
Walker J ,
Wartchow C ,
Aziz N ,
Osborne C ,
Wagner J ,
Sarko C ,
Kelly JM ,
Manjunatha UH ,
Maeser P ,
Jiricek J,
Lakshminarayana SB ,
Barrett MP ,
Diagana TT
(2023) Science , 380 , 1349 - 1356
,
Gould MK ,
Noeske J ,
Saldivia M ,
Jumani RS ,
Ng PS ,
Rene O,
Chen YL ,
Kaiser M ,
Ritchie R ,
Francisco AF ,
Johnson N ,
Patra D,
Cheung H,
Deniston C ,
Schenk AD ,
Cortopassi WA ,
Schmidt RS ,
Wiedemar N ,
Thomas B ,
Palkar R ,
Ghafar NA ,
Manoharan V,
Luu C ,
Gable JE,
Wan KF ,
Myburgh E ,
Mottram JC ,
Barnes W ,
Walker J ,
Wartchow C ,
Aziz N ,
Osborne C ,
Wagner J ,
Sarko C ,
Kelly JM ,
Manjunatha UH ,
Maeser P ,
Jiricek J,
Lakshminarayana SB ,
Barrett MP ,
Diagana TT
(2023) Science , 380 , 1349 - 1356
Grant Support:
- Wellcome Trust: 219639/Z/19/Z (United Kingdom)
- Wellcome Trust: 108517/Z/15/Z (United Kingdom)