EMDB EMD-2974

Single particle reconstruction
4.4Å resolution

The cryoEM map of human gamma-Secretase complex

Map released:
Last modified:
Overview of EMD-2974
Source organism: Homo sapiens [9606]
Fitted atomic model: 4uis
Primary publication:
Structural Basis of Human gamma-secretase Assembly
Sun LF, Zhao LY, Yang GH, Yan CY, Zhou R, Zhou XY, Xie T, Zhao YY, Wu SY, Li XM, Shi YG
PROC.NAT.ACAD.SCI.USA 112 6003-6008 (2015)
PMID: 25918421

Function and Biology Details

Sample name: T4-lysozyme fusion gamma-secretase
Protein: gamma-secretase

Experimental Information Details

Resolution: 4.4Å
Resolution method: FSC 0.143, gold-standard
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: DIRECT ELECTRON DE-12 (4k x 3k)