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EMD-2947
Cryo-electron microscopy structure of the occupied population of CCT5 complexes (mutant huntington oligomer subtrate)
EMD-2947
Subtomogram averaging
Deposition: 24/03/2015Map released: 03/06/2015
Last modified: 22/07/2015
Sample Organism:
Homo sapiens
Sample: CCT5 complex with encapsulated oligomeric mutant huntingtin exon 1.
Deposition Authors: Darrow MC
,
Sergeeva OA ,
Isas JM,
Galaz-Montoya J,
King JA,
Langen R,
Schmid MF ,
Chiu W
Sample: CCT5 complex with encapsulated oligomeric mutant huntingtin exon 1.
Deposition Authors: Darrow MC
,
Sergeeva OA ,
Isas JM,
Galaz-Montoya J,
King JA,
Langen R,
Schmid MF ,
Chiu W
Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by Synthetic Chaperonin-like CCT5 Complex Explained by Cryo-electron Tomography.
Darrow MC ,
Sergeeva OA ,
Isas JM,
Galaz-Montoya J,
King JA,
Langen R,
Schmid MF ,
Chiu W
(2015) J. Biol. Chem. , 290 , 17451 - 17461
,
Sergeeva OA ,
Isas JM,
Galaz-Montoya J,
King JA,
Langen R,
Schmid MF ,
Chiu W
(2015) J. Biol. Chem. , 290 , 17451 - 17461
Secondary citations:
- Sergeeva OA, Chen B, Haase-Pettingel C, Ludtke SJ, Chiu W & King JA. (2013) Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. J. Biol. Chem., 288, 17734 - 17744
- Sergeeva OA, Tran MT, Haase-Pettingell C & King JA. (2014) Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy. J. Biol. Chem., 289, 27470 - 27480