EMD-29081
CryoET tomogram of HD patient iPSC-derived neuron (Q66) with GRSF1 KD treatment
EMD-29081
Tomography
Deposition: 13/12/2022Map released: 22/02/2023
Last modified: 22/02/2023
Sample Organism:
Homo sapiens
Sample: Human neuron differentiated from induced pluripotent stem cells derived from HD patient with a huntingtin gene containing a polyQ tract with 66 Qs with GRSF1 KD treatment
Deposition Authors: Wu GH
,
Smith-Geater C ,
Galaz-Montoya JG ,
Mitchell PG ,
Thompson LM ,
Chiu W
Sample: Human neuron differentiated from induced pluripotent stem cells derived from HD patient with a huntingtin gene containing a polyQ tract with 66 Qs with GRSF1 KD treatment
Deposition Authors: Wu GH
,
Smith-Geater C ,
Galaz-Montoya JG ,
Mitchell PG ,
Thompson LM ,
Chiu W
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.
Wu GH ,
Smith-Geater C ,
Galaz-Montoya JG ,
Gu Y ,
Gupte SR ,
Aviner R,
Mitchell PG ,
Hsu J ,
Miramontes R,
Wang KQ ,
Geller NR,
Hou C ,
Danita C,
Joubert LM ,
Schmid MF ,
Yeung S ,
Frydman J ,
Mobley W,
Wu C,
Thompson LM ,
Chiu W
(2023) Nat Commun , 14 , 692 - 692
,
Smith-Geater C ,
Galaz-Montoya JG ,
Gu Y ,
Gupte SR ,
Aviner R,
Mitchell PG ,
Hsu J ,
Miramontes R,
Wang KQ ,
Geller NR,
Hou C ,
Danita C,
Joubert LM ,
Schmid MF ,
Yeung S ,
Frydman J ,
Mobley W,
Wu C,
Thompson LM ,
Chiu W
(2023) Nat Commun , 14 , 692 - 692
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): P01NS092525 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): S10OD021600 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): R35NS116872 (United States)