EMD-29077

Single-particle
2.62 Å
EMD-29077
3D View Gallery
Deposition: 13/12/2022
Map released: 06/09/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29077

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8fgx summary report (pdf.gz) Map-8fgx FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein

EMD-29077

Single-particle
2.62 Å
EMD-29077
3D View Gallery
Deposition: 13/12/2022
Map released: 06/09/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of STAR-0215 Fab with active plasma kallikrein
Fitted models: 8fgx

Deposition Authors: Fuller JR , Biris N , Bista P
STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema.
Bedian V , Biris N , Omer C, Chung JK, Fuller J, Dagher R, Chandran S, Harwin P, Kiselak T, Violin J, Nichols A, Bista P
(2023) J Pharmacol Exp Ther , 387 , 214 - 225
PUBMED: 37643795
DOI: doi:10.1124/jpet.123.001740
ISSN: 1521-0103
Grant Support: