EMD-28663

Single-particle
3.3 Å
EMD-28663
3D View Gallery
Deposition: 26/10/2022
Map released: 04/09/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28663
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8exx summary report (pdf.gz) Map and 8exx FULL report (pdf.gz)
EMICSS annotations (xml)

Herpes simplex virus 1 polymerase holoenzyme bound to DNA and foscarnet (pre-translocation state)

EMD-28663

Single-particle
3.3 Å
EMD-28663
3D View Gallery
Deposition: 26/10/2022
Map released: 04/09/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human alphaherpesvirus 1 strain KOS, synthetic construct
Sample: Herpes simplex virus 1 polymerase holoenzyme UL30:UL42 in complex with DNA and foscarnet
Fitted models: 8exx

Deposition Authors: Pan J, Abraham J, Coen DM, Shankar S, Yang P, Hogle J
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
Shankar S, Pan J, Yang P, Bian Y, Oroszlan G, Yu Z, Mukherjee P , Filman DJ, Hogle JM, Shekhar M, Coen DM, Abraham J
(2024) Cell , 187 , 5572 - 5586.e15
PUBMED: 39197451
DOI: doi:10.1016/j.cell.2024.07.048
ISSN: 1097-4172