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EMD-28523
Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies
EMD-28523
Single-particle3.4 Å
Deposition: 05/10/2022Map released: 25/01/2023
Last modified: 13/11/2024
Sample Organism:
Mus musculus,
Homo sapiens
Sample: Complex of IL2Rgamma extracellular domain with Fab fragments of antibodies REGN7257 and REGN9432
Fitted models: 8epa
Deposition Authors: Franklin MC
,
Romero Hernandez A
Sample: Complex of IL2Rgamma extracellular domain with Fab fragments of antibodies REGN7257 and REGN9432
Fitted models: 8epa
Deposition Authors: Franklin MC
,
Romero Hernandez A
Blocking common gamma chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A ,
Nagashima K ,
Birchard D ,
Scott G,
Ben LH ,
Ajithdoss D ,
Gayvert K ,
Romero Hernandez A ,
Herbin O ,
Tay A ,
Farrales P,
Korgaonkar CK ,
Pan H,
Shah S,
Kamat V ,
Chatterjee I,
Popke J ,
Oyejide A ,
Lim WK ,
Kim JH,
Huang T ,
Franklin M,
Olson W ,
Norton T ,
Perlee L,
Yancopoulos GD,
Murphy AJ ,
Sleeman MA ,
Orengo JM
(2023) Sci Transl Med , 15 , eabo0205 - eabo0205
,
Nagashima K ,
Birchard D ,
Scott G,
Ben LH ,
Ajithdoss D ,
Gayvert K ,
Romero Hernandez A ,
Herbin O ,
Tay A ,
Farrales P,
Korgaonkar CK ,
Pan H,
Shah S,
Kamat V ,
Chatterjee I,
Popke J ,
Oyejide A ,
Lim WK ,
Kim JH,
Huang T ,
Franklin M,
Olson W ,
Norton T ,
Perlee L,
Yancopoulos GD,
Murphy AJ ,
Sleeman MA ,
Orengo JM
(2023) Sci Transl Med , 15 , eabo0205 - eabo0205
Grant Support: