EMD-28279

Single-particle
3.22 Å
EMD-28279
3D View Gallery
Deposition: 30/09/2022
Map released: 09/08/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28279

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8enu summary report (pdf.gz) Map-8enu FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the C3bB proconvertase in complex with lufaxin

EMD-28279

Single-particle
3.22 Å
EMD-28279
3D View Gallery
Deposition: 30/09/2022
Map released: 09/08/2023
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lutzomyia longipalpis
Sample: The C3 proconvertase from the alternative pathway of complement in complex with lufaxin, a complement inhibitor
Fitted models: 8enu

Deposition Authors: Andersen JF , Lei H
A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Andersen JF , Lei H, Strayer EC , Kanai T, Pham V, Pan XZ, Alvarenga PH , Gerber GF , Asojo OA , Francischetti IMB, Brodsky RA , Valenzuela JG , Ribeiro JMC
(2023) Blood , 141 , 3109 - 3121
PUBMED: 36947859
DOI: doi:10.1182/blood.2022019359
ISSN: 1528-0020