EMD-28036

Single-particle
3.6 Å
EMD-28036
3D View Gallery
Deposition: 05/09/2022
Map released: 27/09/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28036

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8edm summary report (pdf.gz) Map-8edm FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the full-length human NF1 dimer

EMD-28036

Single-particle
3.6 Å
EMD-28036
3D View Gallery
Deposition: 05/09/2022
Map released: 27/09/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Full-length human NF1
Fitted models: 8edm

Deposition Authors: Darling JE, Merk A, Grisshammer R, Ognjenovic J
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Young LC , Goldstein de Salazar R, Han SW , Huang ZYS , Merk A, Drew M , Darling J, Wall V , Grisshammer R, Cheng A , Allison MR, Sale MJ, Nissley DV , Esposito D , Ognjenovic J, McCormick F
(2023) PNAS , 120 , e2208960120 - e2208960120
PUBMED: 36689660
DOI: doi:10.1073/pnas.2208960120
ISSN: 1091-6490
ASTM: PNASA6