EMD-27652

Single-particle
2.8 Å
EMD-27652
3D View Gallery
Deposition: 19/07/2022
Map released: 24/08/2022
Last modified: 05/10/2022
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27652

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

M22 Fab bound to human Thyrotropin receptor (transmembrane domain and G protein map only)

EMD-27652

Single-particle
2.8 Å
EMD-27652
3D View Gallery
Deposition: 19/07/2022
Map released: 24/08/2022
Last modified: 05/10/2022
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: M22 agonist autoantibody bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)

Deposition Authors: Faust B , Cheng Y , Manglik A
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Faust B , Billesbolle CB , Suomivuori CM , Singh I, Zhang K, Hoppe N, Pinto AFM , Diedrich JK, Muftuoglu Y, Szkudlinski MW , Saghatelian A, Dror RO , Cheng Y , Manglik A
(2022) Nature , 609 , 846 - 853
PUBMED: 35940205
DOI: doi:10.1038/s41586-022-05159-1
ISSN: 1476-4687
ASTM: NATUAS