EMD-27647

Single-particle
2.7 Å
EMD-27647
3D View Gallery
Deposition: 18/07/2022
Map released: 24/08/2022
Last modified: 05/10/2022
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27647

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human thyrotropin analog TR1402 bound to human Thyrotropin receptor (extracellular domain map only)

EMD-27647

Single-particle
2.7 Å
EMD-27647
3D View Gallery
Deposition: 18/07/2022
Map released: 24/08/2022
Last modified: 05/10/2022
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human TSH analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)

Deposition Authors: Faust B , Cheng Y , Manglik A
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Faust B , Billesbolle CB , Suomivuori CM , Singh I, Zhang K, Hoppe N, Pinto AFM , Diedrich JK, Muftuoglu Y, Szkudlinski MW , Saghatelian A, Dror RO , Cheng Y , Manglik A
(2022) Nature , 609 , 846 - 853
PUBMED: 35940205
DOI: doi:10.1038/s41586-022-05159-1
ISSN: 1476-4687
ASTM: NATUAS