EMD-27043
Negative stain electron microscopy single particle reconstruction of monoclonal antibody SP1-77 Fab in complex with SARS-CoV2 2P spike
EMD-27043
Single-particle15.0 Å
Deposition: 20/05/2022Map released: 10/08/2022
Last modified: 30/08/2023
Sample Organism:
Mus musculus,
Severe acute respiratory syndrome coronavirus
Sample: Complex of SARS-CoV2 2P spike with SP1-77 antibody Fab
Deposition Authors: Edwards RJ
,
Mansouri K
Sample: Complex of SARS-CoV2 2P spike with SP1-77 antibody Fab
Deposition Authors: Edwards RJ
,
Mansouri K
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.
Luo S ,
Zhang J ,
Kreutzberger AJB ,
Eaton A ,
Edwards RJ ,
Jing C ,
Dai HQ ,
Sempowski GD ,
Cronin K ,
Parks R ,
Ye AY ,
Mansouri K ,
Barr M,
Pishesha N,
Williams AC ,
Vieira Francisco L ,
Saminathan A ,
Peng H ,
Batra H ,
Bellusci L ,
Khurana S ,
Alam SM,
Montefiori DC,
Saunders KO ,
Tian M ,
Ploegh H ,
Kirchhausen T ,
Chen B ,
Haynes BF ,
Alt FW
(2022) Sci Immunol , 7 , eadd5446 - eadd5446
,
Zhang J ,
Kreutzberger AJB ,
Eaton A ,
Edwards RJ ,
Jing C ,
Dai HQ ,
Sempowski GD ,
Cronin K ,
Parks R ,
Ye AY ,
Mansouri K ,
Barr M,
Pishesha N,
Williams AC ,
Vieira Francisco L ,
Saminathan A ,
Peng H ,
Batra H ,
Bellusci L ,
Khurana S ,
Alam SM,
Montefiori DC,
Saunders KO ,
Tian M ,
Ploegh H ,
Kirchhausen T ,
Chen B ,
Haynes BF ,
Alt FW
(2022) Sci Immunol , 7 , eadd5446 - eadd5446
Grant Support:
- Bill & Melinda Gates Foundation: INV-021989 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): UM1-AI144371 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI158571 (United States)