EMD-26678
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
EMD-26678
Single-particle3.1 Å
Deposition: 18/04/2022Map released: 10/08/2022
Last modified: 20/11/2024
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus
Sample: One RBD-up state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment
Fitted models: 7upy
Deposition Authors: Zhang J
,
Luo S ,
Kreutzberger A,
Kirchhausen T ,
Chen B ,
Haynes B,
Alt F
Sample: One RBD-up state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment
Fitted models: 7upy
Deposition Authors: Zhang J
,
Luo S ,
Kreutzberger A,
Kirchhausen T ,
Chen B ,
Haynes B,
Alt F
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.
Luo S ,
Zhang J ,
Kreutzberger AJB ,
Eaton A ,
Edwards RJ ,
Jing C ,
Dai HQ ,
Sempowski GD ,
Cronin K ,
Parks R ,
Ye AY ,
Mansouri K ,
Barr M,
Pishesha N,
Williams AC ,
Vieira Francisco L ,
Saminathan A ,
Peng H ,
Batra H ,
Bellusci L ,
Khurana S ,
Alam SM,
Montefiori DC,
Saunders KO ,
Tian M ,
Ploegh H ,
Kirchhausen T ,
Chen B ,
Haynes BF ,
Alt FW
(2022) Sci Immunol , 7 , eadd5446 - eadd5446
,
Zhang J ,
Kreutzberger AJB ,
Eaton A ,
Edwards RJ ,
Jing C ,
Dai HQ ,
Sempowski GD ,
Cronin K ,
Parks R ,
Ye AY ,
Mansouri K ,
Barr M,
Pishesha N,
Williams AC ,
Vieira Francisco L ,
Saminathan A ,
Peng H ,
Batra H ,
Bellusci L ,
Khurana S ,
Alam SM,
Montefiori DC,
Saunders KO ,
Tian M ,
Ploegh H ,
Kirchhausen T ,
Chen B ,
Haynes BF ,
Alt FW
(2022) Sci Immunol , 7 , eadd5446 - eadd5446
Grant Support:
- Howard Hughes Medical Institute (HHMI): INV-021989 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI127193 (United States)
- Massachusetts Consortium on Pathogen Readiness (MassCPR): SARS-CoV-2 Variants Award (United States)
- Mercatus Center: Emergent Ventures Fast Grant (United States)