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EMD-26508
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS231-P24 (3RBDs open)
EMD-26508
Single-particle5.2 Å
Deposition: 26/03/2022Map released: 08/06/2022
Last modified: 08/06/2022
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Synthetic construct
Sample: SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS231-P24 (3RBDs open)
Deposition Authors: Park YJ
,
Seattle Structural Genomics Center for Infectious Disease (SSGCID),
Veesler D
Sample: SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS231-P24 (3RBDs open)
Deposition Authors: Park YJ
,
Seattle Structural Genomics Center for Infectious Disease (SSGCID),
Veesler D
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Hunt AC ,
Case JB ,
Park YJ ,
Cao L ,
Wu K ,
Walls AC ,
Liu Z ,
Bowen JE ,
Yeh HW ,
Saini S ,
Helms L ,
Zhao YT ,
Hsiang TY ,
Starr TN ,
Goreshnik I ,
Kozodoy L,
Carter L ,
Ravichandran R ,
Green LB,
Matochko WL ,
Thomson CA,
Vogeli B ,
Kruger A ,
VanBlargan LA ,
Chen RE ,
Ying B ,
Bailey AL ,
Kafai NM ,
Boyken SE ,
Ljubetic A ,
Edman N,
Ueda G ,
Chow CM ,
Johnson M ,
Addetia A ,
Navarro MJ ,
Panpradist N ,
Gale Jr M ,
Freedman BS,
Bloom JD ,
Ruohola-Baker H ,
Whelan SPJ ,
Stewart L ,
Diamond MS ,
Veesler D ,
Jewett MC ,
Baker D
(2022) Sci Transl Med , 14 , eabn1252 - eabn1252
,
Case JB ,
Park YJ ,
Cao L ,
Wu K ,
Walls AC ,
Liu Z ,
Bowen JE ,
Yeh HW ,
Saini S ,
Helms L ,
Zhao YT ,
Hsiang TY ,
Starr TN ,
Goreshnik I ,
Kozodoy L,
Carter L ,
Ravichandran R ,
Green LB,
Matochko WL ,
Thomson CA,
Vogeli B ,
Kruger A ,
VanBlargan LA ,
Chen RE ,
Ying B ,
Bailey AL ,
Kafai NM ,
Boyken SE ,
Ljubetic A ,
Edman N,
Ueda G ,
Chow CM ,
Johnson M ,
Addetia A ,
Navarro MJ ,
Panpradist N ,
Gale Jr M ,
Freedman BS,
Bloom JD ,
Ruohola-Baker H ,
Whelan SPJ ,
Stewart L ,
Diamond MS ,
Veesler D ,
Jewett MC ,
Baker D
(2022) Sci Transl Med , 14 , eabn1252 - eabn1252
Grant Support: