EMD-26363

Single-particle
5.03 Å
EMD-26363
3D View Gallery
Deposition: 03/03/2022
Map released: 05/10/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26363

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7u6d summary report (pdf.gz) Map-7u6d FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459

EMD-26363

Single-particle
5.03 Å
EMD-26363
3D View Gallery
Deposition: 03/03/2022
Map released: 05/10/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of non-insulin insulin receptor agonist IM459 bound to the insulin receptor ectodomain (A-isoform) construct IR-A(ecto)
Fitted models: 7u6d

Deposition Authors: Kirk NS , Lawrence MC
Activation of the human insulin receptor by non-insulin-related peptides
Kirk NS , Chen Q , Wu YG, Asante AL, Hu H , Espinosa JF, Martinez-Olid F , Margetts MB , Mohammed FA, Kiselyov VV , Barrett DG , Lawrence MC
(2022) Nat Commun , 13 , 5695
PUBMED: 36171189
DOI: doi:10.1038/s41467-022-33315-8
ISSN: 2041-1723
Grant Support: