EMD-25715

Single-particle
3.6 Å
EMD-25715
3D View Gallery
Deposition: 13/12/2021
Map released: 16/03/2022
Last modified: 28/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25715
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7t6f summary report (pdf.gz) Map and 7t6f FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain

EMD-25715

Single-particle
3.6 Å
EMD-25715
3D View Gallery
Deposition: 13/12/2021
Map released: 16/03/2022
Last modified: 28/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: GCN4-zippered dimeric IFN-lambda intracellular domain bound to two Jak1s
Fitted models: 7t6f

Deposition Authors: Glassman CR , Tsutsumi N , Jude KM , Garcia KC
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Glassman CR , Tsutsumi N , Saxton RA , Lupardus PJ , Jude KM , Garcia KC
(2022) Science , 376 , 163 - 169
PUBMED: 35271300
DOI: doi:10.1126/science.abn8933
ISSN: 1095-9203
ASTM: SCIEAS