EMD-25163

Single-particle
3.3 Å
EMD-25163
3D View Gallery
Deposition: 18/10/2021
Map released: 07/09/2022
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25163

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7sjo summary report (pdf.gz) Map-7sjo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

HtrA1S328A:Fab15H6.v4 complex

EMD-25163

Single-particle
3.3 Å
EMD-25163
3D View Gallery
Deposition: 18/10/2021
Map released: 07/09/2022
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: HtrA1PD/SA bound by Fab15H6.v4 at LoopA epitope
Fitted models: 7sjo

Deposition Authors: Gerhardy S , Green E
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.
Gerhardy S , Ultsch M, Tang W , Green E, Holden JK , Li W, Estevez A, Arthur C, Tom I, Rohou A , Kirchhofer D
(2022) Nat Commun , 13 , 5222 - 5222
PUBMED: 36064790
DOI: doi:10.1038/s41467-022-32760-9
ISSN: 2041-1723
Grant Support: