EMD-25145
Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
EMD-25145
Single-particle5.9 Å
Deposition: 14/10/2021Map released: 19/01/2022
Last modified: 13/11/2024
Sample Organism:
Homo sapiens
Sample: Homodimer human calcium sensing receptor
Fitted models: 7sin
Deposition Authors: Park J, Zuo H
Sample: Homodimer human calcium sensing receptor
Fitted models: 7sin
Deposition Authors: Park J, Zuo H
Symmetric activation and modulation of the human calcium-sensing receptor.
Park J,
Zuo H,
Frangaj A,
Fu Z 
,
Yen LY,
Zhang Z,
Mosyak L,
Slavkovich VN,
Liu J,
Ray KM,
Cao B,
Vallese F,
Geng Y,
Chen S,
Grassucci R,
Dandey VP,
Tan YZ ,
Eng E,
Lee Y,
Kloss B ,
Liu Z,
Hendrickson WA,
Potter CS,
Carragher B ,
Graziano J,
Conigrave AD ,
Frank J,
Clarke OB ,
Fan QR
(2021) PNAS , 118
,
Yen LY,
Zhang Z,
Mosyak L,
Slavkovich VN,
Liu J,
Ray KM,
Cao B,
Vallese F,
Geng Y,
Chen S,
Grassucci R,
Dandey VP,
Tan YZ ,
Eng E,
Lee Y,
Kloss B ,
Liu Z,
Hendrickson WA,
Potter CS,
Carragher B ,
Graziano J,
Conigrave AD ,
Frank J,
Clarke OB ,
Fan QR
(2021) PNAS , 118
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM141871 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM29169 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): P41GM116799 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM107462 (United States)
- Simons Foundation: SF349247 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)