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EMD-25134
Androgen receptor bound to DNA - Divorced state
EMD-25134
Single-particle9.4 Å
Deposition: 11/10/2021Map released: 04/05/2022
Last modified: 22/06/2022
Sample Organism:
Mus musculus,
Homo sapiens
Sample: Androgen receptor bound to DNA - Divorced state
Deposition Authors: Wasmuth EV, Vanden Broeck A, Klinge S, Sawyers CL
Sample: Androgen receptor bound to DNA - Divorced state
Deposition Authors: Wasmuth EV, Vanden Broeck A, Klinge S, Sawyers CL
Allosteric interactions prime androgen receptor dimerization and activation.
Wasmuth EV,
Broeck AV,
LaClair JR,
Hoover EA,
Lawrence KE,
Paknejad N,
Pappas K,
Matthies D,
Wang B 
,
Feng W,
Watson PA,
Zinder JC ,
Karthaus WR ,
de la Cruz MJ,
Hite RK,
Manova-Todorova K,
Yu Z,
Weintraub ST,
Klinge S,
Sawyers CL
(2022) Mol Cell , 82 , 2021 - 2031.e5
,
Feng W,
Watson PA,
Zinder JC ,
Karthaus WR ,
de la Cruz MJ,
Hite RK,
Manova-Todorova K,
Yu Z,
Weintraub ST,
Klinge S,
Sawyers CL
(2022) Mol Cell , 82 , 2021 - 2031.e5
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM140264 (United States)
- Department of Defense (DOD, United States): W81XWH-18-1-0182 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)