EMD-24897

Single-particle
2.54 Å
EMD-24897
3D View Gallery
Deposition: 18/09/2021
Map released: 17/11/2021
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24897
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7s8m summary report (pdf.gz) Map and 7s8m FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14

EMD-24897

Single-particle
2.54 Å
EMD-24897
3D View Gallery
Deposition: 18/09/2021
Map released: 17/11/2021
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: MRGPRX2-Gi1 Cortistatin-14
Fitted models: 7s8m

Deposition Authors: Cao C , Fay JF
Structure, function and pharmacology of human itch GPCRs.
Cao C , Kang HJ , Singh I, Chen H, Zhang C, Ye W , Hayes BW , Liu J , Gumpper RH, Bender BJ, Slocum ST, Krumm BE , Lansu K, McCorvy JD , Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S , Liu Y , Kim K, Karpiak J, Jan LY , Abraham SN, Jin J , Shoichet BK , Fay JF , Roth BL
(2021) Nature , 600 , 170 - 175
PUBMED: 34789874
DOI: doi:10.1038/s41586-021-04126-6
ISSN: 1476-4687
ASTM: NATUAS