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EMD-24794
GLP-1 receptor bound with Pfizer small molecule agonist
EMD-24794
Single-particle3.8 Å
Deposition: 01/09/2021Map released: 08/06/2022
Last modified: 23/10/2024
Sample Organism:
Homo sapiens
Sample: agonist bound GLP1 receptor
Fitted models: 7s15
Deposition Authors: Liu Y, Dias JM
Sample: agonist bound GLP1 receptor
Fitted models: 7s15
Deposition Authors: Liu Y, Dias JM
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Griffith DA 
,
Edmonds DJ,
Fortin JP,
Kalgutkar AS ,
Kuzmiski JB,
Loria PM,
Saxena AR,
Bagley SW ,
Buckeridge C,
Curto JM,
Derksen DR,
Dias JM,
Griffor MC,
Han S,
Jackson VM,
Landis MS,
Lettiere D,
Limberakis C ,
Liu Y,
Mathiowetz AM,
Patel JC,
Piotrowski DW ,
Price DA,
Ruggeri RB ,
Tess DA
(2022) J Med Chem , 65 , 8208 - 8226
,
Edmonds DJ,
Fortin JP,
Kalgutkar AS ,
Kuzmiski JB,
Loria PM,
Saxena AR,
Bagley SW ,
Buckeridge C,
Curto JM,
Derksen DR,
Dias JM,
Griffor MC,
Han S,
Jackson VM,
Landis MS,
Lettiere D,
Limberakis C ,
Liu Y,
Mathiowetz AM,
Patel JC,
Piotrowski DW ,
Price DA,
Ruggeri RB ,
Tess DA
(2022) J Med Chem , 65 , 8208 - 8226
Grant Support: