EMD-24274
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (SAM-TIR:1AD)
EMD-24274
Single-particle4.6 Å
Deposition: 21/06/2021Map released: 23/03/2022
Last modified: 18/05/2022
Sample Organism:
Homo sapiens
Sample: human SARM1 in complex with NMN and 1AD
Deposition Authors: Kerry PS, Adams S, Cunnea K, Brearley A, Bosanac T, Hughes RO, Ve T
Sample: human SARM1 in complex with NMN and 1AD
Deposition Authors: Kerry PS, Adams S, Cunnea K, Brearley A, Bosanac T, Hughes RO, Ve T
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y ,
Kerry PS,
Nanson JD ,
Bosanac T,
Sasaki Y,
Krauss R,
Saikot FK ,
Adams SE,
Mosaiab T,
Masic V,
Mao X,
Rose F,
Vasquez E,
Furrer M,
Cunnea K,
Brearley A,
Gu W,
Luo Z,
Brillault L,
Landsberg MJ ,
DiAntonio A,
Kobe B ,
Milbrandt J,
Hughes RO,
Ve T
(2022) Mol Cell , 82 , 1643 - 1659.e10
,
Kerry PS,
Nanson JD ,
Bosanac T,
Sasaki Y,
Krauss R,
Saikot FK ,
Adams SE,
Mosaiab T,
Masic V,
Mao X,
Rose F,
Vasquez E,
Furrer M,
Cunnea K,
Brearley A,
Gu W,
Luo Z,
Brillault L,
Landsberg MJ ,
DiAntonio A,
Kobe B ,
Milbrandt J,
Hughes RO,
Ve T
(2022) Mol Cell , 82 , 1643 - 1659.e10
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): (Australia)
- Australian Research Council (ARC): (Australia)