EMD-24141

Single-particle
3.33 Å
EMD-24141
3D View Gallery
Deposition: 01/06/2021
Map released: 28/09/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24141

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7n3n summary report (pdf.gz) Map-7n3n FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human NKCC1 state Fu-I

EMD-24141

Single-particle
3.33 Å
EMD-24141
3D View Gallery
Deposition: 01/06/2021
Map released: 28/09/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human NKCC1 in a detergent micelle with furosemide
Fitted models: 7n3n

Deposition Authors: Moseng MA
Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Moseng MA , Su CC , Rios K , Cui M , Lyu M, Glaza P , Klenotic PA , Delpire E , Yu EW
(2022) Sci Adv , 8 , eabq0952 - eabq0952
PUBMED: 36306358
DOI: doi:10.1126/sciadv.abq0952
ISSN: 2375-2548