EMD-23609

Single-particle
2.39 Å
EMD-23609
3D View Gallery
Deposition: 10/03/2021
Map released: 17/03/2021
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23609

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7m05 summary report (pdf.gz) Map-7m05 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

PRMT5 bound to covalent PBM-site inhibitor BRD-6988

EMD-23609

Single-particle
2.39 Å
EMD-23609
3D View Gallery
Deposition: 10/03/2021
Map released: 17/03/2021
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Hetero-octamer complex of PRMT5 and WDR77
Fitted models: 7m05

Deposition Authors: McMillan BJ, McKinney DC
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC , McMillan BJ, Ranaghan MJ , Moroco JA , Brousseau M , Mullin-Bernstein Z , O'Keefe M, McCarren P, Mesleh MF, Mulvaney KM, Robinson F, Singh R, Bajrami B, Wagner FF, Hilgraf R, Drysdale MJ, Campbell AJ, Skepner A, Timm DE, Porter D, Kaushik VK, Sellers WR , Ianari A
(2021) J Med Chem , 64 , 11148 - 11168
PUBMED: 34342224
DOI: doi:10.1021/acs.jmedchem.1c00507
ISSN: 0022-2623
ASTM: JMCMAR