EMD-22740
CryoEM reconstruction of SARS-CoV-2 Spike in complex with the Fab fragment of neutralizing antibody 298
EMD-22740
Single-particle6.2 Å
Deposition: 28/09/2020Map released: 28/10/2020
Last modified: 28/07/2021
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 Spike in complex with the Fab fragment of neutralizing antibody 298
Deposition Authors: Kucharska I, Tan YZ, Benlekbir S, Rubinstein JL, Julien JP
Sample: SARS-CoV-2 Spike in complex with the Fab fragment of neutralizing antibody 298
Deposition Authors: Kucharska I, Tan YZ, Benlekbir S, Rubinstein JL, Julien JP
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Rujas E
,
Kucharska I
,
Tan YZ
,
Benlekbir S,
Cui H,
Zhao T,
Wasney GA,
Budylowski P,
Guvenc F
,
Newton JC,
Sicard T,
Semesi A,
Muthuraman K,
Nouanesengsy A,
Aschner CB,
Prieto K,
Bueler SA,
Youssef S,
Liao-Chan S,
Glanville J,
Christie-Holmes N,
Mubareka S,
Gray-Owen SD
,
Rubinstein JL
,
Treanor B
,
Julien JP
(2021) Nat Commun , 12 , 3661 - 3661
,
Kucharska I
,
Tan YZ
,
Benlekbir S,
Cui H,
Zhao T,
Wasney GA,
Budylowski P,
Guvenc F
,
Newton JC,
Sicard T,
Semesi A,
Muthuraman K,
Nouanesengsy A,
Aschner CB,
Prieto K,
Bueler SA,
Youssef S,
Liao-Chan S,
Glanville J,
Christie-Holmes N,
Mubareka S,
Gray-Owen SD
,
Rubinstein JL
,
Treanor B
,
Julien JP
(2021) Nat Commun , 12 , 3661 - 3661
Grant Support:
- Ontario Ministry of Colleges and Universities: COVID-19 Research Fund C-094-2424972-JULIEN (Canada)
- Canada Foundation for Innovation: (Canada)
- Ontario Research Fund: (Canada)
- The Hospital For Sick Children Foundation: (Canada)
- Canada Research Chairs program: (Canada)
