EMD-22497
SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment (local refinement of the receptor-binding domain and Fab variable domains)
EMD-22497
Single-particle3.6 Å
Deposition: 20/08/2020
Map released: 14/10/2020
Last modified: 27/01/2021
Name: SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment
Summary:
Name:
spike glycoprotein
Name: Natural source [1]
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
Complex Portal [3]
S2A4 neutralizing antibody Fab fragment
Name: Natural source [1]
Organism: Homo sapiens
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Cricetulus griseus | - | - | - |
S2A4 Fab heavy chain
Number of copies: 1
UniProtKB AlphaFold DB
Name: Number of copies: 1
UniProtKB AlphaFold DB
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 13 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Cricetulus griseus | - | - | - |
S2A4 Fab light chain
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 11 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Cricetulus griseus | - | - | - |
Spike glycoprotein
Number of copies: 1
UniProtKB PDBe-KB
Name: Number of copies: 1
UniProtKB PDBe-KB
Domains
Gene Ontology [30]
Biological process:
symbiont-mediated suppression of host innate immune response entry receptor-mediated virion attachment to host cell viral translation virion attachment to host cell suppression by virus of host type I interferon-mediated signaling pathway suppression by virus of host tetherin activity fusion of virus membrane with host plasma membrane fusion of virus membrane with host endosome membrane viral entry into host cell receptor-mediated virion attachment to host cell endocytosis involved in viral entry into host cell membrane fusion positive regulation of viral entry into host cell receptor-mediated endocytosis of virus by host cell
Molecular function:
receptor ligand activity structural constituent of virion identical protein binding host cell surface receptor binding
Cellular location:
host cell surface host extracellular space host cell plasma membrane endoplasmic reticulum-Golgi intermediate compartment integral component of membrane endoplasmic reticulum lumen viral envelope endocytic vesicle membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane virion membrane membrane plasma membrane
symbiont-mediated suppression of host innate immune response entry receptor-mediated virion attachment to host cell viral translation virion attachment to host cell suppression by virus of host type I interferon-mediated signaling pathway suppression by virus of host tetherin activity fusion of virus membrane with host plasma membrane fusion of virus membrane with host endosome membrane viral entry into host cell receptor-mediated virion attachment to host cell endocytosis involved in viral entry into host cell membrane fusion positive regulation of viral entry into host cell receptor-mediated endocytosis of virus by host cell
Molecular function:
receptor ligand activity structural constituent of virion identical protein binding host cell surface receptor binding
Cellular location:
host cell surface host extracellular space host cell plasma membrane endoplasmic reticulum-Golgi intermediate compartment integral component of membrane endoplasmic reticulum lumen viral envelope endocytic vesicle membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane virion membrane membrane plasma membrane
Natural source
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 141 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |