EMD-22490
Structure of human TRPA1 in complex with antagonist compound 21
EMD-22490
Single-particle3.05 Å
Deposition: 20/08/2020Map released: 31/03/2021
Last modified: 06/03/2024
Sample Organism:
Homo sapiens
Sample: TRPA1 bound by antagonist compound 21
Fitted models: 7jup
Deposition Authors: Rohou A, Rouge L, Chen H
Sample: TRPA1 bound by antagonist compound 21
Fitted models: 7jup
Deposition Authors: Rohou A, Rouge L, Chen H
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Terrett JA ,
Chen H ,
Shore DG,
Villemure E,
Larouche-Gauthier R,
Dery M,
Beaumier F,
Constantineau-Forget L,
Grand-Maitre C,
Lepissier L,
Ciblat S,
Sturino C,
Chen Y,
Hu B,
Lu A,
Wang Y,
Cridland AP,
Ward SI,
Hackos DH,
Reese RM,
Shields SD,
Chen J,
Balestrini A,
Riol-Blanco L,
Lee WP,
Liu J,
Suto E,
Wu X,
Zhang J,
Ly JQ,
La H,
Johnson K ,
Baumgardner M,
Chou KJ,
Rohou A,
Rouge L,
Safina BS ,
Magnuson S,
Volgraf M
(2021) J Med Chem , 64 , 3843 - 3869
,
Chen H ,
Shore DG,
Villemure E,
Larouche-Gauthier R,
Dery M,
Beaumier F,
Constantineau-Forget L,
Grand-Maitre C,
Lepissier L,
Ciblat S,
Sturino C,
Chen Y,
Hu B,
Lu A,
Wang Y,
Cridland AP,
Ward SI,
Hackos DH,
Reese RM,
Shields SD,
Chen J,
Balestrini A,
Riol-Blanco L,
Lee WP,
Liu J,
Suto E,
Wu X,
Zhang J,
Ly JQ,
La H,
Johnson K ,
Baumgardner M,
Chou KJ,
Rohou A,
Rouge L,
Safina BS ,
Magnuson S,
Volgraf M
(2021) J Med Chem , 64 , 3843 - 3869