EMDB EMD-22426

Single particle reconstruction
2.9Å resolution

Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution

Map released:
Last modified:
Overview of EMD-22426
Source organism: Rabbit [9986]
Fitted atomic model: 7jpx
Related EM entries by publication: EMD-22414, EMD-22415, EMD-22424, EMD-22425
Primary publication:
Structural Basis of Cav1.1 Modulation by Dihydropyridine Compounds.
Yan N, Gao S
Angew.Chem.Int.Ed.Engl. - (2020)
PMID: 33125829

Function and Biology Details

Sample name: rCav1.1-100A
Ligands: CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, amlodipine
Proteins: rCav1.1-100A, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent calcium channel gamma-1 subunit, Voltage-dependent calcium channel subunit alpha-2/delta-1

Experimental Information Details

Resolution: 2.9Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)