EMDB EMD-22415

Single particle reconstruction
3.4Å resolution

Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom resolution

Map released:
Last modified:
Overview of EMD-22415
Source organism: Rabbit [9986]
Fitted atomic model: 7jpl
Related EM entries by publication: EMD-22414, EMD-22424, EMD-22425, EMD-22426
Primary publication:
Structural Basis of Cav1.1 Modulation by Dihydropyridine Compounds.
Yan N, Gao S
Angew.Chem.Int.Ed.Engl. - (2020)
PMID: 33125829

Function and Biology Details

Sample name: rCav1.1-10S
Ligands: CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, methyl (4~{S})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Proteins: rCav1.1-10S, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent calcium channel gamma-1 subunit, Voltage-dependent calcium channel subunit alpha-2/delta-1

Experimental Information Details

Resolution: 3.4Å
Resolution method: FSC 0.143 CUT-OFF
Detector: GATAN K2 SUMMIT (4k x 4k)