EMDB EMD-22128

Single particle reconstruction
3.66Å resolution

Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 2)

Map released:
Overview of EMD-22128
Fitted atomic model: 6xcn
Related EM entries by publication: EMD-22124, EMD-22125, EMD-22126, EMD-22127
Primary publication:
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
Barnes CO, West AP, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, Hagglof T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ
Cell(Cambridge,Mass.) - (2020)

Function and Biology Details

Sample name: SARS-CoV-2 S 2P trimer complexed with monoclonal Fab fragments from neutralizing antibody C105
Ligands: N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ALPHA-L-FUCOSE
Proteins: SARS-CoV-2 S 2P trimer complexed with monoclonal Fab fragments from neutralizing antibody C105, SARS-CoV-2 spike glycoprotein 2P trimer, neutralizing antibody C105 Fab, Spike glycoprotein, C105 Fab Heavy Chain, C105 Fab Light Chain

Experimental Information Details

Resolution: 3.66Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C3
Reconstruction software: cryoSPARC
Microscope: FEI TITAN KRIOS
Detector: OTHER