EMD-22106

Single-particle
2.6 Å
EMD-22106
3D View Gallery
Deposition: 03/06/2020
Map released: 17/06/2020
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-22106

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-6x9o summary report (pdf.gz) Map-6x9o FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

High resolution cryoEM structure of huntingtin in complex with HAP40

EMD-22106

Single-particle
2.6 Å
EMD-22106
3D View Gallery
Deposition: 03/06/2020
Map released: 17/06/2020
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human huntingtin-HAP40 complex
Fitted models: 6x9o

Deposition Authors: Harding RJ , Deme JC , Lea SM , Arrowsmith CH , Structural Genomics Consortium (SGC)
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.
Harding RJ , Deme JC , Hevler JF, Tamara S , Lemak A, Cantle JP , Szewczyk MM, Begeja N, Goss S, Zuo X , Loppnau P, Seitova A, Hutchinson A, Fan L, Truant R, Schapira M , Carroll JB, Heck AJR , Lea SM , Arrowsmith CH
(2021) Commun Biol , 4 , 1374 - 1374
PUBMED: 34880419
DOI: doi:10.1038/s42003-021-02895-4
ISSN: 2399-3642