EMD-22074

Single-particle
3.6 Å
EMD-22074
3D View Gallery
Deposition: 27/05/2020
Map released: 10/03/2021
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-22074

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-6x6a summary report (pdf.gz) Map-6x6a FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of NLRP1-DPP9 complex

EMD-22074

Single-particle
3.6 Å
EMD-22074
3D View Gallery
Deposition: 27/05/2020
Map released: 10/03/2021
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DPP9-NLRP1 complex
Fitted models: 6x6a

Deposition Authors: Hollingsworth LR , Sharif H , Griswold AR , Fontana P, Mintseris J, Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu H
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Hollingsworth LR , Sharif H , Griswold AR , Fontana P, Mintseris J, Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu H
(2021) Nature , 592 , 778 - 783
PUBMED: 33731932
DOI: doi:10.1038/s41586-021-03350-4
ISSN: 1476-4687
ASTM: NATUAS