EMDB EMD-21950

Single particle reconstruction
3.34Å resolution

Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein

Map released:
Last modified:
Overview of EMD-21950
Source organisms:
Fitted atomic model: 6wwz
Primary publication:
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H
Nat Commun 11 3031-3031 (2020)
PMID: 32541785

Function and Biology Details

Sample name: CCR6-CCL20-Go complex
Proteins: CCR6-CCL20-Go complex, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, C-C motif chemokine 20, Guanine nucleotide-binding protein G(o) subunit alpha,Guanine nucleotide-binding protein G(o) subunit alpha, C-C chemokine receptor type 6,C-C chemokine receptor type 6, scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(o) subunit alpha,Guanine nucleotide-binding protein G(o) subunit alpha, scFv16, C-C chemokine receptor type 6,C-C chemokine receptor type 6

Experimental Information Details

Resolution: 3.34Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)