EMD-21861
Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 mutant R176Q in complex with FKBP12.6 in nanodisc
EMD-21861
Single-particle3.27 Å
Deposition: 25/04/2020Map released: 05/08/2020
Last modified: 29/05/2024
Sample Organism:
Mus musculus,
Homo sapiens
Sample: recombinant mouse Ryanodine Receptor type 2, RyR2, with mutation R176Q in complex with FKBP12.6
Fitted models: 6wou
Deposition Authors: Iyer KA
,
Hu Y,
Kurebayashi N,
Murayama T ,
Samso M
Sample: recombinant mouse Ryanodine Receptor type 2, RyR2, with mutation R176Q in complex with FKBP12.6
Fitted models: 6wou
Deposition Authors: Iyer KA
,
Hu Y,
Kurebayashi N,
Murayama T ,
Samso M
Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.
Iyer KA ,
Hu Y,
Nayak AR ,
Kurebayashi N,
Murayama T ,
Samso M
(2020) Sci Adv , 6 , eabb2964 - eabb2964
,
Hu Y,
Nayak AR ,
Kurebayashi N,
Murayama T ,
Samso M
(2020) Sci Adv , 6 , eabb2964 - eabb2964
Grant Support:
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): R01 AR068431 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R01 HL133182 (United States)
- Other private: MDA 352845 (United States)
- American Heart Association: 19POST34430178 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): HSSN26120080001E (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): U24 GM116789 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): U24 GM116790 (United States)