EMDB EMD-21688

Single particle reconstruction
3.6Å resolution

Structure of human TRPA1 in complex with inhibitor GDC-0334

Map released:
Overview of EMD-21688
Source organism: Homo sapiens [9606]
Fitted atomic model: 6wj5
To be published

Function and Biology Details

Sample name: TRPA1 bound by inhibitor GDC-0334
Ligand: (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide
Proteins: TRPA1 bound by inhibitor GDC-0334, Transient receptor potential cation channel subfamily A member 1

Experimental Information Details

Resolution: 3.6Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: cisTEM
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)