EMDB EMD-21518

Single particle reconstruction
3.35Å resolution

Cryo-EM structure of 5HT3A receptor in presence of Palonosetron

Map released:
Overview of EMD-21518
Source organism: Mus musculus [10090]
Fitted atomic model: 6w1y
Related EM entry by publication: EMD-21511, EMD-21512
Primary publication:
High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S
Elife 9 - (2020)
PMID: 33063666

Function and Biology Details

Sample name: Serotonin receptor
Ligand: (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one
Proteins: Serotonin receptor, 5-hydroxytryptamine receptor 3A

Experimental Information Details

Resolution: 3.35Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER