EMD-21312

Single-particle
10.2 Å
EMD-21312
3D View Gallery
Deposition: 03/02/2020
Map released: 26/08/2020
Last modified: 23/12/2020
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-21312

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM map of C-terminal half of Leucine Rich Repeat Kinase 2 as a WD40-WD40 domain dimer in the presence of the MLi-2 kinase inhibitor at 10.2 angstroms

EMD-21312

Single-particle
10.2 Å
EMD-21312
3D View Gallery
Deposition: 03/02/2020
Map released: 26/08/2020
Last modified: 23/12/2020
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: A WD40-WD40 (10.2A) mediated dimer of truncated Leucine Rich Repeat Kinase 2 in the presence of the MLi-2 kinase inhibitor.

Deposition Authors: Leschziner A, Deniston C, Lahiri I
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
Deniston CK, Salogiannis J , Mathea S , Snead DM , Lahiri I, Matyszewski M , Donosa O , Watanabe R , Bohning J , Shiau AK, Knapp S , Villa E , Reck-Peterson SL , Leschziner AE
(2020) Nature , 588 , 344 - 349
PUBMED: 32814344
DOI: doi:10.1038/s41586-020-2673-2
ISSN: 1476-4687
ASTM: NATUAS