EMDB EMD-21035

Single particle reconstruction
3.7Å resolution

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Map released:
Overview of EMD-21035
Source organism: Rattus norvegicus [10116]
Fitted atomic model: 6v3f
Related EM entry by publication: EMD-21037
Primary publication:
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv 6 eabb1989- (2020)

Function and Biology Details

Sample name: NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Cellular component: NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Ligands: N-ACETYL-D-GLUCOSAMINE, CHOLESTEROL
Protein: NPC1-like intracellular cholesterol transporter 1

Experimental Information Details

Resolution: 3.7Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER