EMDB EMD-20730

Single particle reconstruction
4.26Å resolution

Cryo-EM structure of p97-A232E mutant bound to cofactors UFD1L and NPLOC4

Map released:
Overview of EMD-20730
Source organism: Homo sapiens [9606]
Primary publication:
Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.
Blythe EE, Gates SN, Deshaies RJ, Martin A
Structure - (2019)
PMID: 31623962

Function and Biology Details

Sample name: Complex of p97-A232E and cofactors UFD1L and NPLOC4
Protein: Complex of p97-A232E and cofactors UFD1L and NPLOC4

Experimental Information Details

Resolution: 4.26Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)