EMDB EMD-20725

Single particle reconstruction
4.48Å resolution

Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.

Map released:
Overview of EMD-20725
Source organism: Homo sapiens [9606]
Fitted atomic model: 6uc2
Primary publication:
Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.
Johnson MC, Kollman JM
Elife 9 - (2020)
PMID: 31999252

Function and Biology Details

Sample name: Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.
Cellular component: Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.
Ligands: GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE
Protein: Inosine-5'-monophosphate dehydrogenase 2

Experimental Information Details

Resolution: 4.48Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: D4
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)