EMDB EMD-20722

Single particle reconstruction
7.13Å resolution

Human IMPDH2 treated with ATP and IMP. Fully extended filament segment reconstruction.

Map released:
Overview of EMD-20722
Source organism: Homo sapiens [9606]
Primary publication:
Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.
Johnson MC, Kollman JM
Elife 9 - (2020)
PMID: 31999252

Function and Biology Details

Sample name: Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction.
Cellular component: Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction.

Experimental Information Details

Resolution: 7.13Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: D4
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)