EMDB EMD-20530

Single particle reconstruction
3.74Å resolution

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide

Map released:
Overview of EMD-20530
Source organisms:
Fitted atomic model: 6pza
Related EM entries by publication: EMD-20528, EMD-20533, EMD-20534, EMD-20535
Primary publication:
Mechanism of pharmacochaperoning in a mammalian KATPchannel revealed by cryo-EM.
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
Elife 8 - (2019)
PMID: 31343405

Function and Biology Details

Sample name: KATP-RPG-ATP
Ligands: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE
Proteins: KATP-RPG-ATP, SUR1, KNtp, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11

Experimental Information Details

Resolution: 3.74Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)