EMDB EMD-20490

Single particle reconstruction
4.55Å resolution

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 in saposin nanodiscs

Map released:
Last modified:
Overview of EMD-20490
Source organism: Homo sapiens [9606]
Related EM entries by publication: EMD-20487, EMD-20488, EMD-20489
Primary publication:
Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron - (2019)
PMID: 31488329

Function and Biology Details

Sample name: Human alpha3beta4 nicotinic receptor in complex with Fab fragments and bound to AT-1001
Protein: Human alpha3beta4 nicotinic receptor in complex with Fab fragments and bound to AT-1001

Experimental Information Details

Resolution: 4.55Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)