EMDB EMD-20451

Single particle reconstruction
2.81Å resolution

Cryo-EM structure of human TRPA1 C621S mutant in the apo state

Map released:
Overview of EMD-20451
Source organism: Homo sapiens [9606]
Fitted atomic model: 6pqq
Related EM entry by publication: EMD-20449, EMD-20450
Primary publication:
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Suo Y, Wang Z, Zubcevic L, Hsu AL, He Q, Borgnia MJ, Ji RR, Lee SY
Neuron - (2019)
PMID: 31866091

Function and Biology Details

Sample name: Transient receptor potential cation channel subfamily A member 1
Ligands: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Proteins: Transient receptor potential cation channel subfamily A member 1, Transient receptor potential cation channel subfamily A member 1

Experimental Information Details

Resolution: 2.81Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER