EMDB EMD-20369

Single particle reconstruction
4.2Å resolution

Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+

Map released:
Last modified:
Overview of EMD-20369
Source organism: Danio rerio [7955]
Fitted atomic model: 6pkx
Related EM entries by publication: EMD-20367, EMD-20368, EMD-7822
Primary publication:
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun 10 3740-3740 (2019)
PMID: 31431622

Function and Biology Details

Sample name: Transient receptor potential cation channel subfamily M member 2
Ligands: CALCIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Proteins: Transient receptor potential cation channel subfamily M member 2, Transient receptor potential cation channel subfamily M member 2

Experimental Information Details

Resolution: 4.2Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: FEI FALCON III (4k x 4k)