EMDB EMD-20292

Single particle reconstruction
4.2Å resolution

ZINC9155420-bound TRPV5 in nanodiscs

Map released:
Overview of EMD-20292
Source organism: Oryctolagus cuniculus [9986]
Fitted atomic model: 6pbf
Related EM entry by publication: EMD-20291
Primary publication:
Structure-based characterization of novel TRPV5 inhibitors.
Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, Filizola M, Rohacs T, Moiseenkova-Bell VY
Elife 8 - (2019)
PMID: 31647410

Function and Biology Details

Sample name: ZINC9155420-bound TRPV5 in nanodiscs
Ligand: (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate
Proteins: ZINC9155420-bound TRPV5 in nanodiscs, Transient receptor potential cation channel subfamily V member 5

Experimental Information Details

Resolution: 4.2Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: RELION
Detector: GATAN K2 SUMMIT (4k x 4k)